How does preexisting glaucoma affect the outcomes for penetrating keratoplasty (PKP)?

Updated: Dec 30, 2020
  • Author: Shibandri Das, MD; Chief Editor: Inci Irak Dersu, MD, MPH  more...
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Preexisting glaucoma is frequently more difficult to treat after keratoplasty in both aphakic and pseudophakic eyes. [9]  Preexisting glaucoma has also been determined to be a risk factor for graft failure in multiple studies, including the 10-year Cornea Donor Study. [82, 86]  Reinhard and colleagues [82]  estimated the 3-year graft survival rate in patients with a preoperative history of glaucoma to be 71% in contrast to 89% in patients without such a history. Some studies suggest a higher incidence of graft failure after glaucoma operation performed after PKP. [66]  Hence, in this patient population, it is recommended that the glaucoma operation either precede or be combined with PKP. Clinicians should also be aware that certain indications for transplantation (particularly bullous keratopathy and corneal perforation) are associated with higher risk of developing PKPG.

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