Which histologic findings are characteristic of penetrating keratoplasty and glaucoma (PKPG)?

Updated: Dec 30, 2020
  • Author: Shibandri Das, MD; Chief Editor: Inci Irak Dersu, MD, MPH  more...
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Answer

Chronic elevations of IOP potentially compromise graft endothelial function, leading to graft failure. Depending on its degree and duration, elevated IOP can result in significant endothelial cell loss. After an acute attack of angle-closure glaucoma, endothelial cell loss of 10 to 33% has been reported, and cell loss of 77% has been reported in eyes with acute angle-closure glaucoma lasting more than 12 days. [34]  Morphologic changes in the endothelial cells, such as vacuolization, loosening of cell junctions, blebbing, disruption of the plasma membrane, exkaryocytosis, and loss of whole cells, have been observed in experimentally induced acute glaucoma. [35]  


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