When is penetrating keratoplasty (PKP) contraindicated?

Updated: Dec 30, 2020
  • Author: Shibandri Das, MD; Chief Editor: Inci Irak Dersu, MD, MPH  more...
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Answer

The main contraindication to PKP is inflammation. Regardless of whether the inflammation is caused by currently present ocular disease (eg, bacterial or viral infection, lesions) or trauma, the operation should be postponed until all signs of inflammation have subsided for at least 6 months; however, in the case of trauma from burns caused by chemicals, flames, or molten metals, it is beneficial to wait up to 1 year or until symptoms of photophobia, blepharospasm, or lacrimation have ceased. Any glaucomatous state in an eye must be treated before PKP is performed because failure to do so can cause worsening of glaucoma and rejection of the graft. [32]


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