Which conditions are included in the differential diagnoses of penetrating keratoplasty and glaucoma (PKPG)?

Updated: Dec 30, 2020
  • Author: Shibandri Das, MD; Chief Editor: Inci Irak Dersu, MD, MPH  more...
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The differential diagnosis for increased IOP after PKP includes the following:

  • Nonadherence to application of steroid drops
  • Increased IOP caused by systemic disease such as high blood pressure, heart disease, hypothyroidism, or diabetes
  • Uveitis
  • Suture abscess
  • Corneal infection
  • Recurrent disease in the graft (herpetic or corneal dystrophy

The accurate measurement of IOP in patients who have undergone PKP can be difficult. The diagnosis of PKPG is challenging because of the difficulty in measuring IOP in the corneal graft and the possibility of steroid-induced IOP elevations in the postoperative period. [8]  Nonetheless, IOP is the starting point for the diagnosis of PKPG.

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