Which medications in the drug class Prostaglandin, Ophthalmic are used in the treatment of Acute Angle-Closure Glaucoma (AACG)?

Updated: Jun 20, 2019
  • Author: Albert P Lin, MD; Chief Editor: Inci Irak Dersu, MD, MPH  more...
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Answer

Prostaglandin, Ophthalmic

Increase uveoscleral outflow of the aqueous. One mechanism of action may be through induction of metalloproteinases in ciliary body, which breaks down extracellular matrix, thereby reducing resistance to outflow through ciliary body.

Latanoprost (Xalatan, Xelpros)

Latanoprost may decrease IOP by increasing the outflow of aqueous humor. Patients should be informed about possible cosmetic effects to the eye/eyelashes, especially if uniocular therapy is to be initiated.

Travoprost (Travatan Z)

This agent is a prostaglandin F2-alpha analog. It is a selective FP prostanoid receptor agonist that is believed to reduce IOP by increasing uveoscleral outflow. Travoprost ophthalmic solution is used to treat open-angle glaucoma and ocular hypertension.

Bimatoprost (Lumigan, Latisse)

This agent is a prostamide analog with ocular hypotensive activity. It mimics the IOP-lowering activity of prostamides via the prostamide pathway. Bimatoprost ophthalmic solution is used to reduce IOP in open-angle glaucoma and ocular hypertension.

Latanoprostene bunod ophthalmic (Vyzulta)

Metabolizes rapidly in the eye to latanoprost acid, an F2 alpha prostaglandin analog. May increase the outflow of aqueous humor through the trabecular meshwork and uveoscleral route, which may in turn reduce intraocular pressure.


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