What is the role of chronic lymphocytic leukemia (CLL) in the etiology of glaucoma?

Updated: Jun 25, 2020
  • Author: Andrew A Dahl, MD, FACS; Chief Editor: Hampton Roy, Sr, MD  more...
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The eye may become involved in acute and chronic lymphocytic leukemia and affect the anterior and posterior segment.

Despite a relative high incidence of ocular involvement in leukemia, ranging up to 80%, glaucoma is rare, according to Jakobiec. [6]

Elevated intraocular pressure results from outflow obstruction secondary to iritis, hyphema, pseudohypopyon, or leukemic infiltration of the trabecular meshwork and Schlemm canal, as well as episcleral tissue, which may involve aqueous veins.

Management is primarily through medical means to control intraocular pressure and to address the underlying leukemia through appropriate means.

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