How are intraocular tumors of the retina (retinoblastoma) diagnosed?

Updated: Jun 25, 2020
  • Author: Andrew A Dahl, MD, FACS; Chief Editor: Hampton Roy, Sr, MD  more...
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Answer

Tumors of the retina (retinoblastoma)

The tumor may assume an endophytic or exophytic configuration. In the former configuration, tumor cells may invade into the vitreous and anterior chambers. [3]

In the Wills Eye Hospital series, 17% of 303 patients were associated with glaucoma and iris neovascularization. [1] In another series, glaucoma secondary to retinoblastoma ranged from 2-22%.

Neovascularization is associated with angiogenic factor production from the tumor or ischemia due to large retinal vasculature involvement. Subsequent neovascularization of the iris with angle closure accounts for 73% of glaucoma. Pupillary block leading to angle closure from large tumors and infiltration of the trabecular meshwork account for the remaining cases.


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