Which medications in the drug class Osmotic diuretics are used in the treatment of Hyphema Glaucoma?

Updated: Jul 29, 2020
  • Author: Inci Irak Dersu, MD, MPH; Chief Editor: Hampton Roy, Sr, MD  more...
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Osmotic diuretics

Decrease the IOP by reducing vitreous volume. They increase blood viscosity. Avoidance in patients with sickle cell disease is recommended.

Mannitol (Osmitrol)

When IOP cannot be controlled with topical drops and IOP is high enough to cause optic nerve damage in a short period of time, osmotic diuretics are indicated.

Isosorbide dinitrate (Isordil, Dilatrate-SR)

May be used to abort an acute attack of glaucoma. In the eyes, may create an osmotic gradient between plasma and ocular fluids and induce diuresis by elevating osmolarity of the glomerular filtrate. These effects may, in turn, inhibit tubular reabsorption of water. Treatment is preferred when less risk of nausea and vomiting than that posed by other oral hyperosmotic agents is desired. May be preferred, if the patient tolerates PO intake.

Glycerin (Osmoglyn)

Commercially unavailable; available from compounding pharmacies; oral osmotic agent for reducing IOP. Able to increase tonicity of blood until finally metabolized and eliminated by the kidneys. Maximum reduction of IOP usually occurs 1 h after glycerin administration. Effect usually lasts approximately 5 h.

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