What is the role of orbital radiotherapy in the treatment of Graves ophthalmopathy?

Updated: Apr 17, 2020
  • Author: Sai-Ching Jim Yeung, MD, PhD, FACP; Chief Editor: Romesh Khardori, MD, PhD, FACP  more...
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If no response to therapy occurs in the inflammatory phase, orbital radiotherapy with or without steroids may be tried. Orbital radiotherapy did not increase the risk for radiation-induced tumors or retinopathy, except in patients with diabetes with possible or definite retinopathy. [62] Low-dose radiation from various sources (even if not aimed at the eyes) is linked to cataracts, which may be detected only after long term follow-up. [63] A meta-analysis found better outcome with combining steroids with radiotherapy compared with steroid therapy alone. However, quality-of-life scores were not different between the 2 groups. [64] Diuretics have a limited effect on the edema caused by venous engorgement of the orbit.

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