Which treatments for children with Graves disease have the greatest incidence of adverse events?

Updated: Mar 23, 2018
  • Author: Sai-Ching Jim Yeung, MD, PhD, FACP; Chief Editor: Romesh Khardori, MD, PhD, FACP  more...
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Answer

A study by Yasuda et al of pediatric patients with Graves disease found that a greater incidence and variety of adverse events occurred in those on a high dose of the antithyroid drug methimazole (0.7 or more mg/kg/day) than in those on a low dose (<0.7 mg/kg/day), with the frequencies of adverse events being 50% and 20%, respectively. However, neutropenia and rash were found to manifest independently of dose. [43]


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