What are the signs and symptoms of Graves disease?

Updated: Apr 17, 2020
  • Author: Sai-Ching Jim Yeung, MD, PhD, FACP; Chief Editor: Romesh Khardori, MD, PhD, FACP  more...
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The signs and symptoms of Graves disease, organized by systems, are as follows:

  • General - Fatigue, general weakness

  • Dermatologic - Warm, moist, fine skin; sweating; fine hair; onycholysis; vitiligo; alopecia; pretibial myxedema

  • Neuromuscular - Tremors, proximal muscle weakness, easy fatigability, periodic paralysis in persons of susceptible ethnic groups

  • Skeletal - Back pain, increased risk for fractures

  • Cardiovascular - Palpitations, dyspnea on exertion, chest pain, edema

  • Respiratory - Dyspnea

  • Gastrointestinal - Increased bowel motility with increased frequency of bowel movements

  • Ophthalmologic - Tearing, gritty sensation in the eye, photophobia, eye pain, protruding eye, diplopia, visual loss

  • Renal - Polyuria, polydipsia

  • Hematologic - Easy bruising

  • Metabolic - Heat intolerance, weight loss despite increase or similar appetite, worsening diabetes control

  • Endocrine/reproductive - Irregular menstrual periods, decreased menstrual volume, secondary amenorrhea, gynecomastia, impotence

  • Psychiatric - Restlessness, anxiety, irritability, insomnia

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