Which medications in the drug class Carbonic anhydrase inhibitors are used in the treatment of Posner-Schlossman Syndrome (PSS) (Glaucomatocyclitic Crisis)?

Updated: May 18, 2020
  • Author: Leonard K Seibold, MD; Chief Editor: Hampton Roy, Sr, MD  more...
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Answer

Carbonic anhydrase inhibitors

Carbonic anhydrase is an enzyme found in many tissues of the body, including the eye. It catalyzes a reversible reaction where carbon dioxide becomes hydrated and carbonic acid dehydrated. By slowing the formation of bicarbonate ions with subsequent reduction in sodium and fluid transport, it may inhibit carbonic anhydrase in the ciliary processes of the eye. This effect decreases aqueous humor secretion thus reducing IOP.

Dorzolamide (Trusopt)

Topical formulation of carbonic anhydrase inhibitors.

Acetazolamide (Diamox Sequels)

Oral formulation of carbonic anhydrase inhibitor. Used for adjunctive treatment of chronic simple (open-angle) glaucoma and secondary glaucoma and preoperatively in acute angle-closure glaucoma when delay of surgery desired to lower IOP.


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