What are the treatment options for human leukocyte antigen (HLA) B27–associated psoriatic arthritis?

Updated: Oct 30, 2018
  • Author: Anna Luisa Di Lorenzo, MBBCh; Chief Editor: Andrew A Dahl, MD, FACS  more...
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The mainstay of treatment is patient education with physical and occupational therapy. Nonsteroidal anti-inflammatory drugs reduce joint inflammation and pain. In more severe cases, hydrochloroquine can be beneficial in inducing disease remission. However, it can exacerbate skin involvement. In extensive skin involvement, methotrexate can be used, which relieves both skin lesions and arthritis. Renal and liver function tests and a complete blood cell (CBC) count should be performed frequently, adjusting dosage as necessary. Other effective drugs include sulfasalazine, intramuscular gold, cyclosporine, etretinate, and azathioprine.

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