How does the prevalence of human leukocyte antigen (HLA) B27–associated ankylosing spondylitis vary among races?

Updated: Oct 30, 2018
  • Author: Anna Luisa Di Lorenzo, MBBCh; Chief Editor: Andrew A Dahl, MD, FACS  more...
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Answer

Answer

Initial observations of HLA-B27 association with ankylosing spondylitis were made in whites. Subsequent studies have established the presence of HLA-B27 in patients with ankylosing spondylitis from nearly every ethnic group. A genetic linkage to HLA-B27 has been established since the association of HLA-B27 in ankylosing spondylitis also has been found in families with more than one affected member.


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