What is the role of antibiotics in the treatment of human leukocyte antigen (HLA) B27–associated acute anterior uveitis (AAU)?

Updated: Oct 30, 2018
  • Author: Anna Luisa Di Lorenzo, MBBCh; Chief Editor: Andrew A Dahl, MD, FACS  more...
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Answer

Other emerging therapeutic options include antibiotic therapy in view of the implicated role of gram-negative bacterial infections on triggering HLA-B27 associated AAU. Sulfasalazine treatment has been investigated for its potential role in reducing the number of recurrent attacks of AAU, and prophylactic ciprofloxacin has also been investigated but was not found to be beneficial in view of its adverse effects and cost.

Future novel potential treatments will based on a better understanding of the immune system and will include such substances as cytokines, chemokines, cell adhesion molecules, and T-cell subsets.


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