What is the role of etanercept in the treatment of human leukocyte antigen (HLA) B27–associated acute anterior uveitis (AAU)?

Updated: Oct 30, 2018
  • Author: Anna Luisa Di Lorenzo, MBBCh; Chief Editor: Andrew A Dahl, MD, FACS  more...
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Answer

Answer

Etanercept is a genetically engineered fusion protein, which binds and inactivates both TNF-alpha and TNF-beta. One study showed the efficacy of this protein in improving both ocular inflammation and articular inflammation when injected subcutaneously twice a week for at least 3 months in the treatment of resistant chronic uveitis, including chronic anterior uveitis in children with juvenile rheumatoid uveitis and idiopathic uveitis. This allowed the reduction of both systemic corticosteroids and/or systemic methotrexate.


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