What is the prevalence of human leukocyte antigen (HLA) B27 associated acute anterior uveitis (AAU)?

Updated: Oct 30, 2018
  • Author: Anna Luisa Di Lorenzo, MBBCh; Chief Editor: Andrew A Dahl, MD, FACS  more...
  • Print
Answer

Answer

HLA-B27 associated acute anterior uveitis (AAU) is the most frequent type of endogenous uveitis (see image below), accounting for 18-32% of all anterior uveitis cases in western countries and for 6-13% of all anterior uveitis cases in Asia. The relatively lower frequency in Asia is related to the lower frequency of HLA-B27 found in this population. As mentioned, there are varying global patterns of HLA-B27 associated AAU that may be attributed to different genetic factors, such as HLA-B27 polymorphisms and non-MHC genes. These geographic variations may also exist because of yet unidentified pathogenic environmental factors.

Acute anterior uveitis in ankylosing spondylitis. Acute anterior uveitis in ankylosing spondylitis. Courtesy of Paul Dieppe, BSc, MD, FRCP, FFPHM.

Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!