How many subtypes of human leukocyte antigen (HLA) B27 have been identified?

Updated: Apr 09, 2021
  • Author: Huy D Nguyen, MD, MBA; Chief Editor: Andrew A Dahl, MD, FACS  more...
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The amino acid sequencing of HLA-B27 has been known since 1985. The antigen consists of at least 100 subtypes, with associations existing between some subtypes and other HLA-B27 inflammatory diseases such as anterior uveitis. It is present in only 1.4-8% of the general population (higher in certain Native American groups and Scandinavians). Of patients with acute anterior uveitis, 50-60% may be HLA-B27 positive. Both racial background and national origin affect this rate of incidence. The frequency of HLA-B27 anterior uveitis is lowest in blacks, intermediate in Asians, and highest in whites. [10]

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