Which medications in the drug class Skeletal muscle relaxants are used in the treatment of Congenital Nystagmus (Infantile Nystagmus)?

Updated: Oct 08, 2019
  • Author: Mark Ventocilla, OD, FAAO; Chief Editor: Edsel Ing, MD, MPH, FRCSC  more...
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Skeletal muscle relaxants

Agents used to treat reversible or intractable spasticity are helpful.

Baclofen (Lioresal)

May be effective in reducing nystagmus in adult patients with a history of idiopathic infantile nystagmus. Exact therapeutic mechanism unknown but may relate to inhibition of glutamate release rather than augmentation of GABA-ergic pathways as originally believed. It has been used to treat several types of nystagmus, most commonly PAN.

Improvements in nystagmus intensity appear within minutes and regress after several hours. Medication should not be taken at bedtime or other times when use of eyes is not anticipated.

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