What is the global prevalence of pituitary apoplexy?

Updated: Apr 19, 2019
  • Author: Michael S Vaphiades, DO; Chief Editor: Edsel Ing, MD, MPH, FRCSC  more...
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Answer

Pituitary apoplexy results in an estimated 1.5-27.7% of cases of pituitary adenoma, although the figure is probably closer to 10%.

Mohr and Hardy reviewed hospital records of 664 patients who had surgery for pituitary adenomas. [2] They noted typical symptomatic pituitary apoplexy to occur in only 0.6% of patients with significant hemorrhagic and necrotic changes in 9.5% of surgical specimens.

Frequency of intratumoral hemorrhage increases to 26% if using only MRI criteria without clinical evidence of apoplexy. However, hemorrhagic pituitary apoplexy may be fatal. Kurisu et al reported a 68-year-old man who developed pituitary apoplexy resulting in massive intracerebral hemorrhage and death 1 month later. [3]


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