Which medications in the drug class Immune Globulins are used in the treatment of Stevens-Johnson Syndrome?

Updated: Jan 17, 2019
  • Author: C Stephen Foster, MD, FACS, FACR, FAAO, FARVO; Chief Editor: Andrew A Dahl, MD, FACS  more...
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Answer

Immune Globulins

These agents are used to improve clinical and immunologic aspects of the disease. They may decrease autoantibody production, and they may increase solubilization and removal of immune complexes.

Immune globulin intravenous (Gammaplex, Hizentra, Octagam, Privigen, Gammagard S/D)

IVIG neutralizes circulating myelin antibodies through anti-idiotypic antibodies; down-regulates proinflammatory cytokines, including interferon-gamma; blocks Fc receptors on macrophages; suppresses inducer T and B cells and augments suppressor T cells; blocks complement cascade; and promotes remyelination. IVIG may increase IgG levels (by 10%) in the cerebrospinal fluid.


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