What is the role of cyclosporine in the treatment of Stevens-Johnson syndrome (SJS)?

Updated: Jan 17, 2019
  • Author: C Stephen Foster, MD, FACS, FACR, FAAO, FARVO; Chief Editor: Andrew A Dahl, MD, FACS  more...
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Answer

The role of other immunosuppressive therapy, that is, cyclosporine, azathioprine, or cyclophosphamide, in the acute phase is less popular, particularly since such medication typically takes weeks to begin to influence immunological reactions. Cyclophosphamide has been reported to be the culprit drug that induced Stevens-Johnson syndrome in one instance. [42]

Nevertheless, the role of cyclosporine in the treatment of the acute phase of Stevens-Johnson syndrome has been revisited, and, indeed, it showed encouraging results. [10] Also, immunosuppressive therapy may play a pivotal role in the management of the chronic ocular surface inflammation that can occur later on in selected cases.


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