Why are randomized studies with a placebo control lacking in Stevens-Johnson syndrome (SJS)?

Updated: Jan 17, 2019
  • Author: C Stephen Foster, MD, FACS, FACR, FAAO, FARVO; Chief Editor: Andrew A Dahl, MD, FACS  more...
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Answer

For any intervention, a prospective randomized controlled trial would be the most appropriate step to validate its use. However, a large number of patients are required to reach statistical significance. Furthermore, for ethical reasons, withdrawal of a potentially life-saving therapy for the sake of randomization with a placebo control is not possible.


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