What are the recommended treatments for skin care in Stevens-Johnson syndrome (SJS) and which biologic dressings are used?

Updated: Jan 17, 2019
  • Author: C Stephen Foster, MD, FACS, FACR, FAAO, FARVO; Chief Editor: Andrew A Dahl, MD, FACS  more...
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Answer

Several skin care approaches have been described. Extensive debridement of nonviable epidermis, followed by immediate cover with biologic dressings, are among the recommended treatments. Biologic dressings may include the following:

  • Porcine cutaneous xenografts

  • Cryopreserved cutaneous allografts

  • Amnion-based skin substitutes

  • Collagen-based skin substitutes

The ophthalmology literature supports concurrent coverage of the involved eye(s) with amniotic membrane. [35]

Leaving the involved epidermis that has not yet peeled off in place and using biologic dressings only on raw dermis also has been recommended. Skin allotransplantation reduces pain, minimizes fluid loss, improves heat control, and prevents bacterial infection. Hyperbaric oxygen can also improve healing.


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