What are dermal and epidermal histopathologic findings in Stevens-Johnson syndrome (SJS)?

Updated: Jan 17, 2019
  • Author: C Stephen Foster, MD, FACS, FACR, FAAO, FARVO; Chief Editor: Andrew A Dahl, MD, FACS  more...
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Answer

In the dermis, CD4+ T lymphocytes predominate, whereas in the epidermis, the T cells are predominantly CD8+. The dermoepidermal junction and epidermis is infiltrated mostly by CD8+ T lymphocytes. Complement 3 component and immunoglobulin G (IgG) deposits at the dermoepidermal junction and around small dermal vessels were interpreted as the result of a nonspecific exudative phenomenon. The activated state is underlined by human leukocyte antigen (HLA)-DR expression on keratinocytes, similar to other skin inflammatory disorders.


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