How are typical histopathologic findings characterized in Stevens-Johnson syndrome (SJS)?

Updated: Jan 17, 2019
  • Author: C Stephen Foster, MD, FACS, FACR, FAAO, FARVO; Chief Editor: Andrew A Dahl, MD, FACS  more...
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Answer

Minimal dermal inflammatory cell infiltrate and full-thickness necrosis of epidermis are typical histopathologic findings in patients with Stevens-Johnson syndrome. The epidermal-dermal junction shows changes, ranging from vacuolar alteration to subepidermal blisters. The dermal infiltrate is superficial and mostly perivascular. Keratinocytes undergo apoptosis.


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