How is the severity of the cutaneous reaction a risk factor for mortality in Stevens-Johnson syndrome (SJS)?

Updated: Jan 17, 2019
  • Author: C Stephen Foster, MD, FACS, FACR, FAAO, FARVO; Chief Editor: Andrew A Dahl, MD, FACS  more...
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Answer

In a survival analysis of a cohort of patients with either Stevens-Johnson syndrome or toxic epidermal necrolysis, Sekula et al found that the severity of the cutaneous reaction causing either of these disorders was a risk factor for mortality, but only during the first 90 days following reaction onset. [33] The investigators also found that serious comorbidities and age were risk factors for mortality after 90 days, but not beyond 1 year, past reaction onset. Mortality among patients was 23% at 6 weeks and 34% at 1 year.


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