What is the role of allopurinol and lamotrigine in the pathogenesis of Stevens-Johnson syndrome (SJS) and how is the risk mitigated?

Updated: Jan 17, 2019
  • Author: C Stephen Foster, MD, FACS, FACR, FAAO, FARVO; Chief Editor: Andrew A Dahl, MD, FACS  more...
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Higher doses and rapid introduction of allopurinol [13] and lamotrigine [14] may also increase the risk of developing SJS/TEN. Risk is lessened by starting these at the low doses and titrating gradually. [15]

There is evidence that systemic lupus is a risk factor as well. [16]

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