What is the pathogenesis of Stevens-Johnson syndrome (SJS) and which patient populations are at greatest risk?

Updated: Jan 17, 2019
  • Author: C Stephen Foster, MD, FACS, FACR, FAAO, FARVO; Chief Editor: Andrew A Dahl, MD, FACS  more...
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Answer

An idiosyncratic, delayed hypersensitivity reaction has been implicated in the pathophysiology of Stevens-Johnson syndrome. Certain population groups appear more susceptible to develop Stevens-Johnson syndrome than the general population. Slow acetylators, patients who are immunocompromised (especially those infected with HIV [3, 4] ), and patients with brain tumors undergoing radiotherapy with concomitant antiepileptics are among those at most risk.


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