What ocular signs may be noted on slit-lamp exams in Stevens-Johnson syndrome (SJS)?

Updated: Jan 17, 2019
  • Author: C Stephen Foster, MD, FACS, FACR, FAAO, FARVO; Chief Editor: Andrew A Dahl, MD, FACS  more...
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Answer

The following ocular signs may be noted on slit-lamp examination:

  • Eyelids: Trichiasis, distichiasis, meibomian gland dysfunction, blepharitis

  • Conjunctiva: Papillae, follicles, keratinization, subepithelial fibrosis, conjunctival shrinkage, foreshortening of fornices, symblepharon, ankyloblepharon

  • Cornea: Superficial punctate keratitis, epithelial defect, stromal ulcer, neovascularization, keratinization, limbitis, conjunctivalization, stromal opacity, perforation (see the image below)

    A patient with severe eye involvement associated w A patient with severe eye involvement associated with Stevens-Johnson syndrome. Note corneal neovascularization and conjunctivalization of the ocular surface.

See Clinical Presentation for more detail.


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