Which medications in the drug class Immunosuppressant agents are used in the treatment of Peripheral Ulcerative Keratitis?

Updated: Jun 11, 2019
  • Author: Ellen N Yu-Keh, MD; Chief Editor: Andrew A Dahl, MD, FACS  more...
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Answer

Immunosuppressant agents

Inhibit key factors that mediate immune response.

Tacrolimus ointment (Protopic)

Macrolide antibiotic that shares many pharmacologic properties with cyclosporine, and is similar in effects but does not produce cytotoxicity. Tacrolimus suppresses cell-mediated immunity by inhibiting DNA translation of specific lymphokines and the expression of the interleukin-2 receptor on activated T cells.

Methotrexate (Folex PFS, Rheumatrex)

A folic acid analog. Acts on the enzyme dihydrofolate reductase, which catalyses the reduction of folate to tetrahydrofolate, a compound necessary for DNA synthesis. Actively replicating cells, such as the leukocyte, are affected and their functions suppressed.

Azathioprine (Imuran)

A purine nucleoside analog that is activated in the liver producing metabolites, which interfere with purine metabolism. T- and B-cell functions are suppressed.

Cyclosporin A (Sandimmune, Neoral, SangCyA)

An 11-amino acid cyclic peptide and a natural product of fungi. Cyclosporine acts on T-cell replication and activity.

Cyclophosphamide (Cytoxan)

Nitrogen mustard derivative, which affects cell replication by alkylating purines in DNA and RNA.

Chlorambucil (Leukeran)

Slow-acting nitrogen mustard derivative, which interferes with DNA replication, transcription, and nucleic acid function by alkylation.


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