What is the ocular prognosis of ankylosing spondylitis?

Updated: May 15, 2020
  • Author: Jean Deschênes, MD, FRCSC; Chief Editor: Hampton Roy, Sr, MD  more...
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Answer

Answer

HLA-B27 typing is not necessary to establish the diagnosis of ankylosing spondylitis, but it is a useful prognostic indicator in patients with uveitis.

Patients with ankylosing spondylitis and the HLA-B27 antigen tend to develop uveitis at a younger age, have a longer duration of ocular disease, and have more recurrences. Additionally, patients who are HLA-B27 positive appear to have more severe disease in terms of anterior chamber inflammation and vitreitis, resulting in a higher incidence of complications and the requirement for more aggressive therapy.

The ocular prognosis is dependent on the ability to control the inflammatory response.


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