What is the role of medications in the treatment of glucose-6-phosphate dehydrogenase (G6PD) deficiency?

Updated: Jun 25, 2020
  • Author: Lawrence C Wolfe, MD; Chief Editor: George T Griffing, MD  more...
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Pharmacologic therapy is not used in glucose-6-phosphate dehydrogenase (G6PD) deficiency. Prophylactic oral phenobarbital does not decrease the need for phototherapy or exchange transfusions in G6PD-deficient neonates. [40]

The heme analogue tin-mesoporphyrin (SnMP) has been successful in inhibiting bilirubin production in newborns but remains an experimental agent. [41]

Transcriptional upregulation of G6PD enzyme in response to histone deacetylase inhibitors in in-vitro experiments on human B cells and erythroid precursor cells has been reported by Makarona et al, which opens new areas of potential treatment in future. [37]

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