How is glucose-6-phosphate dehydrogenase (G6PD) deficiency treated?

Updated: Jun 25, 2020
  • Author: Lawrence C Wolfe, MD; Chief Editor: George T Griffing, MD  more...
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Most individuals with glucose-6-phosphatase dehydrogenase (G6PD) deficiency do not require any treatment. However, infants with prolonged neonatal jaundice as a result of G6PD deficiency should receive phototherapy, and exchange transfusion may be necessary in cases of severe neonatal jaundice or hemolytic anemia caused by favism.

Systematic assessment for the risk of severe hyperbilirubinemia should be performed before discharge in neonates in whom G6PD deficiency is suspected, so that early and focused follow-up can be provided to prevent kernicterus. [10, 11, 12]

Anemia secondary to mild to moderate hemolysis in G6PD-deficient patients is usually self-limited and often resolves in 8-14 days. Transfusion is rarely needed in cases of severe anemia.

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