Which clinical history findings are characteristic of glucose-6-phosphate dehydrogenase (G6PD) deficiency-related chronic nonspherocytic hemolytic anemia?

Updated: Jun 25, 2020
  • Author: Lawrence C Wolfe, MD; Chief Editor: George T Griffing, MD  more...
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Answer

Chronic nonspherocytic hemolytic anemia

A small percentage of G6PD-deficient patients have chronic nonspherocytic hemolytic anemia of variable severity. G6PD Brighton, G6PD Harilaou, and G6PD Serres are included in this category. [1, 18, 37]

The patient with chronic nonspherocytic hemolytic anemia is usually a male with a history of neonatal jaundice who may present with anemia, unexplained jaundice, or gallstones later in life. Although they have chronic hemolysis, the patients are also vulnerable to acute oxidative damage on exposure to an oxidative agent. [18]


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