How is glucose-6-phosphate dehydrogenase (G6PD) deficiency treated in a neonate?

Updated: Jun 25, 2020
  • Author: Lawrence C Wolfe, MD; Chief Editor: George T Griffing, MD  more...
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Answer

Infants with prolonged neonatal jaundice as a result of G6PD deficiency should receive phototherapy. Exchange transfusion may be necessary in cases of severe neonatal jaundice.

Systematic assessment for the risk of severe hyperbilirubinemia should be performed before discharge in neonates in whom G6PD deficiency is suspected, to provide early and focused follow-up to prevent kernicterus (bilirubin encephalopathy). [10, 11, 12]  Consultations with a hematologist are ideal for long-term follow up.

See Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency for more information on management in adults.


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