What are indications for testing for glucose-6-phosphate dehydrogenase (G6PD) deficiency?

Updated: Jun 25, 2020
  • Author: Lawrence C Wolfe, MD; Chief Editor: George T Griffing, MD  more...
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Answer

Indications for testing for glucose-6-phosphatase dehydrogenase (G6PD) deficiency include the following:

  • Development of hemolysis after taking medications or experiencing conditions that  induce oxidative stress especially in patients of African, Mediterranean, or Asian descent.
  • Unexplained severe or prolonged neonatal hyperbilirubinemia with poor response to phototherapy.
  • Family history suggestive of G6PD deficiency especially among males.
  • Recurrent jaundice, splenomegaly, or cholelithiasis in patients of African, Mediterranean, or Asian descent. [4]  
  • Nonspherocytic hemolytic anemia (since the underlying cause might be severe G6PD deficiency and chronic hemolysis)

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