How does the WHO classify the variants of glucose-6-phosphate dehydrogenase (G6PD) deficiency?

Updated: Jun 25, 2020
  • Author: Lawrence C Wolfe, MD; Chief Editor: George T Griffing, MD  more...
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Answer

The World Health Organization has classified the different G6PD variants according to the degree of enzyme deficiency and severity of hemolysis, as follows: [27]

  • Class I - Severe enzyme deficiency, chronic nonspherocytic hemolysis
  • Class II - Severe enzyme deficiency (1-10% residual activity), intermittent acute hemolysis
  • Class III - Moderate enzyme deficiency (10-60% residual activity), intermittent acute hemolysis
  • Class IV - No enzyme deficiency (60-150% activity)
  • Class V - Increased enzyme activity (>150%)

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