What is the role of ranibizumab in the treatment of choroidal neovascularization (CNV)?

Updated: Jul 27, 2020
  • Author: Lihteh Wu, MD; Chief Editor: Andrew A Dahl, MD, FACS  more...
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Ranibizumab is a recombinant monoclonal antibody Fab fragment that neutralizes all active forms of VEGF-A.

Ranibizumab is delivered as a monthly intravitreal injection.

The US Food and Drug Administration approved the use of ranibizumab for the treatment of all angiographic subtypes of subfoveal neovascular ARMD.

Intravitreal ranibizumab is the first treatment that significantly improves visual acuity in up to 40% of eyes. [37] An extension study of patients who completed 1 of 3 different randomized clinical trials of ranibizumab for exudative age-related macular degeneration showed that intravitreal injections of ranibizumab were well tolerated for more than 4 years. However, less frequent follow-up led to fewer injections, which in turn led to a loss of the initial gains in visual acuity. [38]

Although infrequent, complications associated with this treatment include endophthalmitis and severe uveitis.

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