What is the role of fluorescein angiography (FA) in the workup of choroidal neovascularization (CNV)?

Updated: Jul 27, 2020
  • Author: Lihteh Wu, MD; Chief Editor: Andrew A Dahl, MD, FACS  more...
  • Print

Fluorescein angiography (FA) is an essential tool in diagnosing and managing CNV. Several angiographic patterns have been described for CNV.

A lesion that hyperfluoresces in the early phases of the angiogram, maintains well-demarcated borders, and leaks late (obscuring its borders) is a classic CNV.

A lesion whose borders cannot be determined by FA is an occult CNV. Fibrovascular pigment epithelial detachment (PED) and late leakage of undetermined source (LLUS) represent patterns of occult CNV. A fibrovascular PED is a lesion that is elevated solidly and hyperfluoresces irregularly to different degrees. The lesion may be well demarcated or poorly demarcated. LLUS is seen during FA as an irregular, indistinct, late, sub-RPE leakage.

According to its location relative to the center of the fovea, CNV has been classified as extrafoveal (200-1500 µm), juxtafoveal (1-199 µm), and subfoveal.

Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!