Which fluorescein angiography (FA) findings are characteristic of choroidal neovascularization (CNV)?

Updated: Jul 27, 2020
  • Author: Lihteh Wu, MD; Chief Editor: Andrew A Dahl, MD, FACS  more...
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FA was once an essential tool in diagnosing and managing CNV. Spectral domain OCT has largely replaced FA as the imaging modality of choice in the management of CNV. Angiographic patterns that have been described for CNV include the following:

  • A lesion that hyperfluoresces in the early phases of the angiogram, maintains well-demarcated borders, and leaks late (obscuring its borders) – Classic CNV
  • A lesion whose borders cannot be determined by FA – Occult CNV
  • A lesion, well demarcated or poorly demarcated, that is elevated solidly and hyperfluoresces irregularly to different degrees – Fibrovascular pigment epithelial detachment (PED); a form of occult CNV
  • A lesion that demonstrates irregular, indistinct, late, sub-RPE leakage – Late leakage of undetermined source (LLUS); a form of occult CNV

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