What is the modified Callender classification for choroidal melanoma histology?

Updated: Feb 18, 2020
  • Author: Enrique Garcia-Valenzuela, MD, PhD; Chief Editor: Andrew A Dahl, MD, FACS  more...
  • Print


The most commonly used histologic classification of uveal melanomas is the modified Callender classification, which divides uveal melanocytic tumors into the following groups:

  • Spindle cell nevi

  • Spindle cell melanomas

  • Necrotic melanomas

  • Epithelioid cell melanomas

  • Mixed cell melanomas

The last 2 carry the poorest survival prognoses. Evaluation of vascular supply of the tumor, age at presentation, presence of extrascleral extension, tumor size, tumor cell types, mitotic rate, nucleolar area, and quantification of nucleolar organizer regions have been used for prognostic purposes.

Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!