What is the role of lab tests in the workup of choroidal melanoma?

Updated: Feb 18, 2020
  • Author: Enrique Garcia-Valenzuela, MD, PhD; Chief Editor: Andrew A Dahl, MD, FACS  more...
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The most common site of choroidal melanoma metastasis is the liver. Liver enzyme levels are indicated in any patient with uveal melanoma. The most sensitive tests of hepatic function are serum levels of alkaline phosphatase, glutamic-oxaloacetic transaminase, lactate dehydrogenase, and gamma-glutamyl transpeptidase.

These test results are negative at the time of diagnosis in most patients with choroidal melanoma. If any of these laboratory test results are abnormal, order ultrasonography and computed tomography (CT) of the liver. Unfortunately, both imaging modalities have low sensitivity for metastasis smaller than 10-20 mm in diameter.

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