Which medications in the drug class Amylinomimetic agents are used in the treatment of Glucose Intolerance?

Updated: Jun 28, 2019
  • Author: Samuel T Olatunbosun, MD, FACP, FACE; Chief Editor: George T Griffing, MD  more...
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Answer

Amylinomimetic agents

Pramlintide is an amylinomimetic agent that modulates gastric emptying, prevents postprandial increases in plasma glucagon, and promotes satiety, leading to decreased caloric intake and potential weight loss. [49, 50, 51, 52, 53, 81]

Although naturally occurring human amylin is unsuitable for clinical use because of several physicochemical properties (eg, poor solubility; self-aggregation; formation of b-pleated sheets, amyloid fibrils, amyloid plaques), the selective substitution of the amino acid proline for Ala25, Ser28, and Ser29 addresses the suboptimal physicochemical properties of human amylin while preserving the important metabolic actions. Pramlintide acetate injection, which contains this amylin analogue, is a sterile, clear, colorless, aqueous solution that also contains mannitol for isotonicity and the preservative m-cresol.

Pramlintide (SymlinPen)

Pramlintide is a synthetic analogue of human amylin, a naturally occurring hormone made in pancreas beta cells. Pramlintide slows gastric emptying, suppresses postprandial glucagon secretion, and regulates food intake through centrally mediated appetite modulation. It is indicated to treat type 1 or type 2 diabetes in combination with insulin.

Pramlintide is administered before meals in patients who have not achieved desired glucose control despite optimal insulin therapy. The drug helps to achieve lower blood glucose levels after meals, less fluctuation of blood glucose levels during the day, and improvement of long-term control of glucose levels (ie, HbA1c levels) compared with insulin alone. Reductions in insulin use and body weight are also observed.


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