Which medications in the drug class Dipeptidyl Peptidase-IV Inhibitors are used in the treatment of Glucose Intolerance?

Updated: Jun 28, 2019
  • Author: Samuel T Olatunbosun, MD, FACP, FACE; Chief Editor: George T Griffing, MD  more...
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Answer

Dipeptidyl Peptidase-IV Inhibitors

The DPP-4 inhibitors are oral agents that inactivate the major enzyme responsible for degrading incretin hormones in vivo.

Sitagliptin (Januvia)

Sitagliptin blocks the enzyme DPP-4, which is known to degrade incretin hormones. Sitagliptin increases concentrations of active intact incretin hormones (GLP-1 and GIP). The hormones stimulate insulin release in response to increased blood glucose levels following meals. This action enhances glycemic control. Sitagliptin is indicated for diabetes type 2 as monotherapy or in combination with metformin or with a peroxisome proliferator-activated receptor gamma agonist (eg, thiazolidinediones).

Saxagliptin (Onglyza)

Saxagliptin blocks the enzyme DPP-4, which is known to degrade incretin hormones. It increases concentrations of active intact incretin hormones (GLP-1 and GIP). The hormones stimulate insulin release in response to increased blood glucose levels following meals. This action enhances glycemic control. Saxagliptin is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.


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