Which clinical history findings are characteristic of type 1 diabetes mellitus (DM)?

Updated: Jun 28, 2019
  • Author: Samuel T Olatunbosun, MD, FACP, FACE; Chief Editor: George T Griffing, MD  more...
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Answer

The warning symptoms of type 1 diabetes include polyuria, polydipsia, and polyphagia due to hyperglycemia. Patients may present with the unexplained weight loss and easy fatigability that result from reduced glucose use and increased catabolism.

Irritability, drowsiness, and loss of consciousness may occur, especially as ketoacidosis develops. The temporal profile is consequent to progression of the metabolic derangement, which is characterized by dehydration, electrolyte abnormalities, osmolality, and acid-base disturbances. After presentation with ketoacidosis, a patient may briefly revert to normoglycemia without requiring therapy (ie, the honeymoon remission).


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