What is the role of intracameral tissue plasminogen activator (t-PA) in the treatment of hyphema?

Updated: Jan 18, 2019
  • Author: David L Nash, MD; Chief Editor: Andrew A Dahl, MD, FACS  more...
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Some studies have investigated the application of intracameral tissue plasminogen activator (t-PA) in the management of traumatic hyphema. [56] However, these studies have been neither large nor randomized. A potential problem with t-PA is the associated risk of rebleeding of the initial wound.

Application of t-PA has been considered in resolving hyphemas that either fail to clear spontaneously or are associated with malignant intraocular pressure, [57] although the actual timing of t-PA administration from the initial injury has yet to be determined.

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