Which medications in the drug class Antidepressants, SSRIs are used in the treatment of Sleep Dysfunction in Women?

Updated: Jan 31, 2019
  • Author: Gila Hertz, PhD, ABSM; Chief Editor: Selim R Benbadis, MD  more...
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Answer

Antidepressants, SSRIs

SSRIs are generally well tolerated and are currently the most frequently prescribed drugs for the treatment of depression. Pharmacologic treatment with antidepressants is indicated for PMDD, postpartum depression, and clinical depression in patients of any age.

Serotonin noradrenaline reuptake inhibitors (SNRIs) are also used. These agents exhibit noradrenergic and serotonergic effects in patients with depression.

Sertraline (Zoloft)

Sertraline is effective for the treatment of clinical depression in women. It is also indicated for panic disorders and obsessive-compulsive disorders.

Escitalopram oxalate (Lexapro)

Escitalopram oxalate is prescribed for insomnia associated with depression. A selective serotonin reuptake inhibitor (SSRI) and an S-enantiomer of citalopram, it is used for the treatment of depression. Its mechanism of action is thought to be the potentiation of serotonergic activity in the central nervous system (CNS) resulting from the inhibition of the CNS neuronal reuptake of serotonin. The onset of depression relief may be obtained after 1-2 weeks, which is sooner than for other antidepressants.

Fluoxetine hydrochloride (Sarafem)

Fluoxetine hydrochloride has been approved for the treatment of PMDD. It is indicated for the treatment of premenstrual insomnia associated with PMDD.


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