Which medications in the drug class Stimulants are used in the treatment of Sleep Dysfunction in Women?

Updated: Jan 31, 2019
  • Author: Gila Hertz, PhD, ABSM; Chief Editor: Selim R Benbadis, MD  more...
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These agents may be effective in narcolepsy.

Modafinil (Provigil)

Modafinil's mechanism or mechanisms of action in wakefulness are unknown. It has wake-promoting actions like sympathomimetic agents.

Armodafinil (Nuvigil)

Armodafinil is an R-enantiomer of modafinil (mixture of R- and S-enantiomers). It elicits wake-promoting actions similar to those of sympathomimetic agents, although its pharmacologic profile is not identical to sympathomimetic amines. In vitro, armodafinil binds to the dopamine transporter and inhibits dopamine reuptake. It is not a direct- or indirect-acting dopamine receptor agonist. Armodafinil is indicated for the improvement of wakefulness in individuals with excessive sleepiness associated with narcolepsy, obstructive sleep apnea-hypopnea syndrome (OSAHS), or shift-work sleep disorder.

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