What is the role of medications in the treatment of children with narcolepsy?

Updated: Sep 04, 2019
  • Author: Sagarika Nallu, MD; Chief Editor: Selim R Benbadis, MD  more...
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Answer

For children younger than 7 years who have narcolepsy, pemoline was previously considered the initial drug of choice. However, the FDA concluded that the overall risk of liver toxicity from pemoline outweighed the benefits, and the drug was removed from the US market in 2005.

Currently, no FDA-approved pharmacotherapy is available for children with narcolepsy. However, the medications used to treat narcolepsy in adults have been used off-label in the pediatric population with positive results. In particular, methylphenidate and modafinil have proved effective for patients 6-15 years old. [61]


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